Today 17:20 Live on Sky Sports 2
Top Industry Price
First Goalscorer: Billy Sharp - 6/1
Leeds odds to win - 2/1
Draw - 12/5
Southampton odds to win - 13/10
Leeds are without defender Alex Bruce who has been sidelined with a hamstring strain he suffered against Portsmouth.
New signing Danny Webber is unlikely to be involved as he is short of match fitness and Mika Vayrynen is out.
Southampton are hoping top scorer Rickie Lambert can shake off an ankle knock sustained against Watford.
Midfielder Adam Lallana will be given a late check on a groin injury, full-back Frazer Richardson (thigh) is a doubt but Guly do Prado should return.
These clubs have gone head-to-head 90 times in league and cup fixtures. Leeds have won 44, Southampton 26, with a share of the spoils in 20. Southampton are looking for a third successive win against the Whites, and their second double over them in five years. The first goal scored in this game will be the 250th in competitive matches between the pair. Leeds need to net four times to take their total against Saints to 150.
United have slipped out of the play-off places after an inconsistent spell of four wins in nine games, and three losses in six. Leeds have scored 52 Championship goals; only Blackpool and Southampton have netted more. Of those, an unrivalled 10 have been netted in stoppage time.
The Saints defend their one point lead at the summit, and will be looking for a third straight victory to give them their best winning run for three months. Nigel Adkins's side have bagged 10 points out of 12, and have built a six-game unbeaten sequence, but are still to beat a top-half club away from home. The Hampshire side have won 16 of the 18 Championship games in which they opened the scoring.